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VITROCELL® 12/12 now available with Climatic Chamber
The VITROCELL® 12/12 module system has been designed to facilitate the exposure of mammalian cell cultures to airborne substances such as gases, complex mixtures, nanoparticles and fibers. It features a throughput of 3 dilution steps @ 3 replicates and 1 clean air control at 3 replicates. In order to optimize the exposure for liquid aerosols and to maximize the performance of humidified air supply it is now also available in a user-friendly climatic chamber. Exposure at the Air/Liquid Interface In response to the scientific need to expose in physiologically relevant conditions, the VITROCELL® exposure devices have been specifically designed to enable direct exposure of mammalian cells or tissue at the Air/Liquid…
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New Video: VITROCELL® Cloud α – for Aerosol Research and Cell Exposure at the Air/Liquid Interface (ALI)
The VITROCELL® Cloud Alpha series is our newest innovation and presents a great leap forward in automated exposure of cell cultures. It combines reliable exposure of cell cultures from the respiratory tract with ease of use. This series is our new take on the well-known and frequently published VITROCELL® Cloud systems (6-, 12- and 24-well). Its functionality enables fully automated processes with an all-in-one control unit. Everyday experiments at the air/liquid interface have never been easier. The Cloud system is suitable for nebulization of solutions and suspensions. Possible fields of application are screening of inhaled drugs, virus research toxicity testing of inhaled substances such as chemicals or nanoparticles. In response…
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VITROCELL® Shisha Testing System for Cell Cultures
. Background Emissions of water pipe tobacco can now be tested by in vitro exposure in a reliable and user-friendly setup. The novel Shisha Testing Device can be combined with any VITROCELL® Exposure System. The same setup can also be expanded for chemical analysis of Shisha emissions. Solution The Shisha Testing System consists of the following components: 1. Shisha Testing Device 2. VC 1 Smoking Machine 3. Cell Culture Exposure System 1. Shisha Testing Device The device follows the specifications of ISO 22486. The system can be operated with charcoal or via electrical heating. The water pipe tobacco holder is made of ceramics and holds approx. 25 ml of tobacco. The electrical…
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VITROCELL® Cloud Alpha 96
The VITROCELL® Cloud Alpha 96 is our newest innovation and presents a great leap forward in automated exposure of cell cultures. It combines high throughput testing with ease of use. The development is based on the well-known and frequently published VITROCELL® Cloud formats (6-, 12- and 24-well). It’s functionality enables fully automated processes with an all-in-one control unit. Everyday experiments at the air/liquid interface have never been easier. The new Cloud Alpha 96 series was developed as a result of numerous customer requests and is now capable to expose mammalian cell cultures in Corning ® HTS Transwell ® 96-Well Permeable Support Systems. The Cloud system is suitable for nebulization of…
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VITROCELL® holder systems for e-cigarettes
New designs of electronic cigarettes such as ENDS (Electronic Nicotine Delivery Systems) products or HTP (Heated Tobacco Products) lead to a large variety of different shapes which make the insertion into conventional holders with labyrinth seals impossible. VITROCELL® has developed a new holder system which is flexible to adjust to different shapes. Thus, all e-cigarettes can be used. The compatibility is tested with JUUL, myblu, Alto, Logic, IQOS, vype, GLO and tank products. VITROCELL®️ holders are tight, very solidly worked out, durable and easy to clean. They are compatible with all VITROCELL® Smoking Machines & Robots. In most cases the exchange of the inner sealing is sufficient to adjust for a…
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VITROCELL® TEM Grid holders for dose determination of airborne particles during in vitro Exposure at the air / liquid interface
. Background The assessment of toxicological effects of airborne particles to the human organism is of major importance in disease research. The presence of nano and ultrafine particles can be found both in indoor and outdoor atmospheres which include workplaces and living areas. Over the last years, the degree of contribution to diseases of such particles is analyzed ever more frequent by the use of in vitro methods. The required equipment for these studies consisting of aerosol generation and exposure systems are nowadays developed more and more to proven levels. Here the exposure of lung cells to particles at the air/liquid interface is the prime choice over submerse exposure conditions…
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Screening antiviraler pharmazeutischer Leitwirkstoffe gegen das Coronavirus (COVID-19 / SARS-CoV-2)
In der Inhalationstherapie werden pharmazeutische Präparate als Aerosole auf Zellen des Atemtraktes im Nasen- oder Lungenbereich appliziert. Zur präklinischen Entwicklung neuer Arzneimittel werden dafür oft kommerziell erhältliche, physiologisch relevante in vitro Zellkulturmodelle des Nasen-, Rachen- oder Lungenepithels verwendet. In jüngster Zeit wurden diese Modelle verfeinert, um SARS-CoV-2 Infektionen nachzuahmen. Bei der Entwicklung neuer Arzneimittel war es bisher üblich, die Zellkulturen ganz mit Zellkulturmedium zu bedecken und die zu testenden Wirkstoffe ins Zellkulturmedium zu geben. Dieses submerse Expositionsverfahren stellt allerdings eine unphysiologische Applikationsform dar, da die Substanzen mit dem Zellkulturmedium interagieren und die Zellen demnach eine andere Dosis und Formulierung erhalten können als ursprünglich geplant. Darüber hinaus produzieren Lungenepithelzellen in submersen…
