• Biotechnik

    Dry Powder Exposure of Air-Liquid Interface (ALI) Cell Cultures: VITROCELL PowderX System

    The VITROCELL PowderX Exposure System is the ideal tool for aerosolisation of small quantities of dry powders and particle deposition on cells cultured in 12- or 24-well sized inserts. It is designed for evaluation of pharmaceutical compounds and toxicological evaluation of particles and fibres. Small powder samples of 1–100 mg are positioned in the quick-lock loading system. Subsequent aerosolisation of the powder takes place under high pressure by a unique jet system. The resulting shear forces facilitate deagglomeration for homogeneous dispersion into the expansion chamber. Final deposition takes place via gravimetric settling. The height of the expansion chamber can be varied in three different steps according to the behaviour and…

    Kommentare deaktiviert für Dry Powder Exposure of Air-Liquid Interface (ALI) Cell Cultures: VITROCELL PowderX System
  • Biotechnik

    96-well Exposure of Air-Liquid Interface (ALI) Cell Cultures on HTS Plates: New VITROCELL® 96 Continuous Flow Exposure System

    The VITROCELL® 96 Continuous Flow Exposure System represents a breakthrough in high-throughput research involving human cell cultures or tissues exposed directly to airborne substances such as gases, complex mixtures and particles, including nanoparticles. This innovative system faithfully replicates the conditions of human physiological exposure at the Air-Liquid Interface (ALI). With the capacity to perform up to 11 dilutions, each with 8 replicates, and dedicating the 12th insert row for clean air control with also 8 replicates, the 96-well plates offer exceptional versatility, allowing for the assessment of multiple endpoints in a single experiment. Key Features The VITROCELL® 96 Exposure System provides a comprehensive 96-well turnkey solution that includes all necessary…

    Kommentare deaktiviert für 96-well Exposure of Air-Liquid Interface (ALI) Cell Cultures on HTS Plates: New VITROCELL® 96 Continuous Flow Exposure System
  • Biotechnik

    In vitro lung cell exposure systems by VITROCELL at EUROTOX 2023

    VITROCELL displayed the latest lung cell exposure systems for liquid aerosols at EUROTOX 2023: Cloud Alpha 12, Cloud Alpha TRIO, Cloud Alpha MOVE and the lung-on-chip system Cloud Alpha AX12.  The Cloud Alpha product group is particularly well suited for exposure of lung cells to scarce and expensive materials, such as new drug candidates or particle samples from the environment. The new advanced dry powder exposure system PowderX catched also a lot of interest. It is specially designed for aerosolisation of smallest quantities of dry powders. The need for only 1-100 mg of test substance makes the system a powerfull tool for lung cell exposure of scarce and very expensive…

  • Biotechnik

    Exposure of Lung Cells to Liquid Aerosols at the Air/Liquid Interface

    Good Things Come in Threes: This latest member of the Cloud Alpha family features the delivery of three different aerosol concentrations or three different substances in one experiment. The latter  procedure is particularly interesting for users which need to test and compare larger numbers of different substances. The new Cloud Alpha TRIO is capable to expose mammalian cell cultures in 12-and 24-well sized inserts. The Cloud system is suitable for nebulization of solutions and suspensions. Fields of application are screening of inhalable drugs, assessing the toxicity of inhaled substances like chemicals or nanoparticles, and conducting research on viruses. Each aerosol exposure compartment has its dedicated Quartz Crystal Microbalance to assess…

    Kommentare deaktiviert für Exposure of Lung Cells to Liquid Aerosols at the Air/Liquid Interface
  • Medizintechnik

    Dynamic Spirit of Innovation: 2nd MPS World Summit in Berlin

    The 2023 World Summit for microphysiological systems (MPS) had a record attendence with over 1,200 participants from all over the world. The increase of attendees from 700 at the 2022 MPS Meeting in New Orleans showed the dynamics in this emerging field. 196 speakers reported on their research using organs-on-chip. The conference started with a very successful Educational Workshop where VITROCELL explained the exposure to the AlveoliX AX12 lung-on-chip using the exposure system Cloud Alpha AlveoliX AX12. Clémentine Richter from the Helmholtz Institute for Pharmaceutical Research Saarland, Saarbrücken, Germany presented her poster on alveolar inflammation illustrating human drug response using the Cloud Alpha AlveoliX AX12 (See Poster) The exhibition gave…

  • Biotechnik

    VITROCELL® Remote Assist Support

      VITROCELL in-vitro-Expositionssysteme werden spezifisch nach Kundenwunsch gefertigt. Unsere Kunden aus ­Forschung & Entwicklung haben meist sehr komplexe Anforderungen an die Anlage. Daher werden Produktschulungen sowie Service & Support von qualifizierten VITROCELL Technikern durchgeführt. Für VITROCELL Anwender auf der ganzen Welt möchten wir stets eine schnelle Reaktion und Problemlösung ermöglichen. Live Assistance mit Augmented Reality Eine enorme Erleichterung bietet hier der Einsatz von Augmented Reality. Bei VITROCELL setzen wir auf die HoloLens 2 von Microsoft. Sie erlaubt unserem Support, in Echtzeit passgenaue Anleitungen zu geben. Das Sichtfeld des Anwenders wird auf den Monitor des Technikers übertragen. Dieser kann so eine Schulung der Anlage aus der Ferne durchführen, oder Möglichkeiten zur…

  • Biotechnik

    VITROCELL® AES for toxicity testing of airborne particles

    DOI:10.3791/61210 Hedwig M. Braakhuis1, Ruiwen He1,2, Rob J. Vandebriel1, Eric R. Gremmer1, Edwin Zwart1, Jolanda P. Vermeulen1, Paul Fokkens1, John Boere1, Ilse Gosens1, Flemming R. Cassee1,2 1National Institute for Public Health and the Environment (RIVM)  2Institute for Risk Assessment Sciences (IRAS)  This article provides a method for culturing and exposing the human bronchial epithelial cell line Calu-37 at the Air-liquid Interface that mimics realistic, repeated inhalation exposure conditions that can be used for toxicity testing. By applying a continuous airflow using the Automated Exposure System, the cell model can be exposed to a low concentration of particles over a longer time period, reflecting realistic exposure conditions. Characteristics of both the…

  • Medizintechnik

    New VITROCELL® Millicell Holder

    The revolutionary new holder system enables for the use of standing inserts in all modules of the VITROCELL® 12 Series for 12-well sized inserts. As an additional advantage, the media com­partment is sealed towards the aerosol exposure head to avoid contact of the test substance with the cell culture media. VITROCELL® Holder system set: Insert holder with o-ring Adaptor Insert mounting tool Holder removal tool Mounting procedure: Place the adaptor in the exposure module. Then mount the insert in the insert holder using the insert mounting tool. Place the insert holder with the mounted insert into the adaptor. Make sure that no air bubbles are situated under the membrane: add…

  • Medizintechnik

    The New VITROCELL® RH/T-Controller

    The VITROCELL® RH/T-Controller system was designed to measure temperature and relative humidity in numerous applications at high precision. It can be fitted to humidification systems, aerosol ducts and climatic chambers. In cell exposure, relative humidity is a key factor for cell viability – this is even more important at longer exposure durations. With the new RH/T Controller set VITROCELL® has brought the technology from the Automated Stations to custom configurations. The sensors are availabe in 2 insertion lengths ( 35 mm and 65 mm). They come calibrated with a factory certificate. Re-calibration can be performed using the VITROCELL® Monitor software. VITROCELL® Monitor Software The VITROCELL® RH/T-Controller can be operated as…

  • Biotechnik

    VITROCELL® Cloud Alpha Family

    The VITROCELL® Cloud α series for automated exposure of cell cultures has been enlarged and now comprises the Cloud Alpha 6, Cloud Alpha 12, Cloud Alpha 96 and Cloud Alpha MAX. They represent an optimal solution for everyday cell exposure experiments at the Air/Liquid Interface using 6-well, 12-well, 24-well or 96-sized inserts. The product solutions combine reliable exposure of cell cultures from the respiratory tract with ease of use. This video showcases available product configurations. Über die VITROCELL Systems GmbH Advanced in vitro exposure systems Firmenkontakt und Herausgeber der Meldung: VITROCELL Systems GmbH Fabrik Sonntag 3 79183 Waldkirch Telefon: +49 (7681) 4977950 http://www.vitrocell.com Ansprechpartner: Tobias Krebs Managing Director Telefon: +49 (7681)…