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Again Breaking News from NIH for biomedical research
The U.S. The National Institutes of Health (NIH) has announced an investment of more than $150 million to advance human‑based research methods and reduce reliance on animal models. This funding represents the first awards under the Complement Animal Research in Experimentation (Complement‑ARIE) program, focused on developing, validating, and standardizing new approach methodologies (NAMs) — including advanced in vitro and computational models that better reflect human biology. Key elements of the initiative include: Establishment of Technology Development Centers to accelerate NAM development A NAMs data hub and coordinating center to support data sharing and standards A validation and qualification network to enable regulatory acceptance through public‑private collaboration Initial pilot projects in areas such as inhalation toxicity, developmental neurotoxicity,…
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New Video: Advancing Engine Emissions Research at SR Technicss
Following the successful installation of the VITROCELL AirTox Monitor at the SR Technics Group test facilities, we’re excited to see it already fully integrated into ongoing emissions research. Watch the video: https://lnkd.in/de49AXcG In collaboration with the Adolphe Merkle Institute and ZHAW School of Engineering, advanced in vitro exposure at the air–liquid interface is now being applied to deepen the understanding of jet engine emissions. We’re looking forward to further progress within the JETSTREAM project and to driving innovation in next-generation in vitro testing methods. More Information Firmenkontakt und Herausgeber der Meldung: VITROCELL Systems GmbH Fabrik Sonntag 3 79183 Waldkirch Telefon: +49 (7681) 4977950 http://www.vitrocell.com Ansprechpartner: Tobias Krebs Managing Director Telefon:…
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Why suspend a powder if you don’t have to?
Dry Powder Exposure Systems enable the direct aerosolization of dry powders — without first transferring them into suspension. This exposure principle is especially valuable when: only very small quantities of material are available test substances should be evaluated in their native particulate form maximum material efficiency is required By aerosolizing dry powders directly into the exposure chamber, researchers can generate dose-response profiles while preserving scarce and high-value materials, such as novel drug candidates. At which stage does dry powder exposure become critical in your research workflow? More information Firmenkontakt und Herausgeber der Meldung: VITROCELL Systems GmbH Fabrik Sonntag 3 79183 Waldkirch Telefon: +49 (7681) 4977950 http://www.vitrocell.com Ansprechpartner: Tobias Krebs Managing…
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Why comparability matters in dosimetry
Results of inline photometer can only be interpreted with confidence when data is aligned across systems, setups, and over time. In practice, this is often challenging due to: Variability in aerosol generation Effects related to test article Taking this one step further, we are introducing a new approach to inline photometer harmonization: Factory harmonization using a defined reference (“Golden Photometer”) Standardized aerosol generation for reproducible conditions Isokinetic sampling directly from the aerosol flow Digital calibration instead of manual adjustment Validation through linearity testing Result: comparable data across devices, labs and experimental runs. Benefit: reduced setup efforts and increased confidence in generated data. Because in the end, it’s not just about…
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What makes VITROCELL unique?
It is not one single feature, one product, or one technical specification. It is the combination of things that matter when in vitro exposure systems are used in real research environments: Innovation Solutions tailored to specific research questions, from aerosol generation to exposure and dosimetry. Reliability Systems designed for long-term use, stable performance, and demanding laboratory routines. Quality Structured processes, careful testing, and ISO 9001-certified operations to support consistent results. Service Because advanced systems need more than installation. With V-CARE, we support laboratories with training, maintenance, technical expertise, and fast response when it matters. Sustainability Durable systems, responsible material choices, and a long-term view on product design and support. For us,…
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Know your dose. Improve your data.
All in a single, controlled run: fewer moving parts, cleaner curves. Why it helps your stats • Parallel replicates in one go – generate key data under identical conditions • Stable environment – water-heated base and exposure top for uniform temperature and healthy cells • Hygienic, durable build – electropolished medical grade stainless steel; fully autoclavable Dosimetry without losing balance Use the fourth position for dosimetry and still keep three for exposure and three for sham: • QCM for real-time deposited mass (ng/cm²·s) • Stainless-steel liquid trapping insert – a simple, hands-on way to capture particle and gas constituents for qualitative or quantitative analysis • TEM Grid Holder – for…
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How do you get NAMs-ready, human relevant data on anesthetic safety?
The debate on anesthetic effects in the developing brain has been stuck on mixed and often non-human data. FDA/NCTR used neural stem cell models and trusted VITROCELL SC3 Exposure Systems to keep xenon or desflurane, O₂, and CO₂ rock steady during long exposures. When the atmosphere stays steady, the biology speaks. Neuroprotection revealed: In human neurons, 33% xenon blunted propofol-induced damage and preserved key markers and morphology. Conditional toxicity pinpointed: In primate neurons, desflurane showed toxicity only in differentiated cells and only after a 24 hour exposure. Shorter exposure and undifferentiated cells were largely unaffected. These are not just results. They show what becomes visible when your exposure system does not…
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New Research Highlight: Validating the VITROCELL Cloud Alpha MOVE
We’re proud to see our technology featured in the latest poster by Matthew Sheavyn & Victoria Pack from Dstl. Dstl is one of the principal government organisations dedicated to science and technology in the defence and security field, located in Porton Down, UK. Their work underscores the importance of characterizing and validating advanced in vitro inhalation exposure systems before deploying them in research projects. In their study, the VITROCELL Cloud Alpha MOVE was rigorously tested and demonstrated: ✅ A low variation in delivered dose across all 24 positions (±6%) ✅ High deposition efficiency: 75.3% (determined via fluorescence-based FNA assay) and 72.4% (measured using an integrated QCM) ✅ A clear, stepwise…
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Organ-on-Chip (OoC) Exposure – From Gas to Dry Powders in One Complete Solution
Vitrocell and AlveoliX set the benchmark in Organ-on-chip technology, delivering complete aerosol capability on chip for lung, skin and eye exposure. The AlveoliX Barrier-on-chip, especially the breathable lung-on-chip model, enables unmatched flexibility for inhalation research at the air-liquid interface. Vitrocell’s advanced exposure systems accommodate all aerosol types for the AlveoliX AX12 – from gas and vapor phases to liquid aerosols and dry powders – enabling realistic, precise, and reproducible testing conditions. This versatility empowers researchers to explore the full range of respiratory exposure scenarios under human-relevant conditions, from environmental pollutants, over combustion aerosols, to cutting-edge therapeutics. Are you interested? Discover the options here: Product News Organ-on-Chip Exposure Über die VITROCELL…
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New Application Note: Precise Dry Powder Analysis with VITROCELL sQCM 12
Tired of unreliable QCM results when working with dry particles? Irregular deposition and weak bonding are a common challenge in nanoparticle research. That’s why we developed the new VITROCELL Dry Powder Kit – optimized for use with PowderX! This innovative kit ensures stable and reproducible dry powder deposition, enabling precise dose monitoring with the VITROCELL sQCM 12 sensor. ✅ Stable & reproducible dry powder deposition measurement ✅ User-friendly post-processing procedure for seamless integration ✅ Integrated data analysis in VITROCELL Monitor Software Easy and precise dosimetry: Post-treatment stabilizes particles into a rigid layer, enabling accurate mass deposition calculations via Sauerbrey’s equation. A one-time calibration allows direct dosimetry within PowderX. Important to…
