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Real-world airborne exposure meets in vitro precision
Vitrocell exposure systems enable direct air–liquid interface (ALI) exposure of mammalian cells and tissues to real-world airborne substances. From gases, complex mixtures, and combustion exhausts to cigarette smoke, e-cigarette vapor, household chemicals, nanomaterials, pharmaceutical aerosols, dry powders, and even viruses, Vitrocell supports high-quality in vitro inhalation research. Vitrocell helps teams generate reliable, reproducible data for toxicology, pharmaceutical development, and safety testing, while reducing reliance on animal studies and accelerating innovation. Interested in your use case? Let’s connect. More Information Firmenkontakt und Herausgeber der Meldung: VITROCELL Systems GmbH Fabrik Sonntag 3 79183 Waldkirch Telefon: +49 (7681) 4977950 http://www.vitrocell.com Ansprechpartner: Tobias Krebs Managing Director Telefon: +49 (7681) 4977950 E-Mail: info@vitrocell.com Weiterführende Links…
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Why Air–Liquid Interface exposure is a game-changer for inhalation research
In traditional submerged cell culture, airway cells are covered by liquid – a condition that does not reflect how humans actually breathe. At the Air–Liquid Interface (ALI), mammalian cells and tissues are exposed directly to airborne substances, replicating human respiratory physiology more closely and producing more predictive, human-relevant results. From toxicology to pharmaceutical development and safety testing, ALI exposure allows researchers to generate reliable, reproducible data while reducing the reliance on animal studies. Why and when are you using submerged exposure? More information Firmenkontakt und Herausgeber der Meldung: VITROCELL Systems GmbH Fabrik Sonntag 3 79183 Waldkirch Telefon: +49 (7681) 4977950 http://www.vitrocell.com Ansprechpartner: Tobias Krebs Managing Director Telefon: +49 (7681) 4977950…
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Real-world airborne exposure meets in vitro precision
Not all test atmospheres can be tested the same way. Some require the Continuous Flow Exposure Principle. In our Continuous Flow Exposure Systems, mammalian cells, tissues, and ex vivo material can be exposed to a constant flow of gases, complex mixtures, or particles – allowing both gas and particle phases to be assessed simultaneously. Furthermore, the method is fully compatible with organ-on-chip exposure using the AlveoliX AX12. The Continous Flow exposure principle is indispensable when: • long-term exposure is required • all phases of a test atmosphere are relevant • testing materials / atmosphere is available in sufficient quantities for a longer-term continuous delivery Depending on the Exposure System, exposures…
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When advanced exposure technology is used for environmental research
Following successful factory acceptance testing at Vitrocell in Waldkirch, we recently completed the final user training for the AirTox Monitor systems at LISA – Laboratoire Interuniversitaire des Systèmes Atmosphériques, (Université Paris Cité/Université Paris-Est Créteil (UPEC)/CNRS, France). What often matters most at this stage is not the system itself – but how confidently research teams can integrate it into their existing workflows. Working with a highly motivated and interdisciplinary team of researchers/engineers from Université Paris Cité, UPEC, CNRS and INSERM, the focus of the training was on practical application, data interpretation, and real-world usability in ongoing inhalation research projects. With both AirTox Monitor systems now fully implemented, we are looking forward…
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New study by French Armed Forces research team: Pollutant mixtures trigger early lung effects long before acute toxicity appear
In a recently published study, researchers from the Institut de Recherche Biomédical des Armées (IRBA) and INERIS carried out repeated, sub-lethal co-exposures to aluminum oxide nanoparticles (Al₂O₃ NPs) and hydrogen chloride (HCl). A human air–liquid interface co-culture model of alveolar epithelial cells and fibroblasts was exposed using the VITROCELL Cloud System. Key findings: No loss of cell viability or barrier integrity No induction of classical inflammatory or fibrotic markers But: activation of markers for fibroblast proliferation and migration was detected The results suggest that “silent” epithelial stress from mixed airborne pollutants may initiate early lung damage through unconventional epithelial–mesenchymal crosstalk—an aspect that may be missed by standard toxicity endpoints. This…
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Why nebulizer output rates matter in the VITROCELL Cloud System
Only when output rates are well controlled can we ensure that the same amount of aerosol reaches all positions in the system, enabling homogeneous deposition and robust, reproducible exposure conditions. To support this, our systems are equipped with an internal logger that tracks nebulizer performance over time. This allows users to monitor nebulizer condition throughout its lifetime and provides guidance on when cleaning or inspection is required. Taking this one step further To ensure that the best possible equipment is available right from the start of every experiment, we have now decided to introduce certified nebulizer output rates: Nebulizers are extensively tested in-house Output rates are verified and certified Devices are thoroughly cleaned and…
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What if your test substance is rare and you have only microliters to work with?
Single Droplet Sedimentation Systems are designed for dose-controlled, spatially uniform deposition of liquid aerosols at the Air–Liquid Interface. This exposure principle is ideal when: you work with liquid samples or suspensions materials are scarce or highly valuable precise dose control is required short, repeatable exposures are sufficient Aerosols are generated from small solution or suspension volumes and applied directly into the exposure chamber – making this method particularly suitable for early-stage drug candidates, chemicals, or environmental samples. Which liquid aerosols (or suspension-based test substances) are you currently trying to deposit more reproducibly? More information Firmenkontakt und Herausgeber der Meldung: VITROCELL Systems GmbH Fabrik Sonntag 3 79183 Waldkirch Telefon: +49 (7681)…
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Again Breaking News from NIH for biomedical research
The U.S. The National Institutes of Health (NIH) has announced an investment of more than $150 million to advance human‑based research methods and reduce reliance on animal models. This funding represents the first awards under the Complement Animal Research in Experimentation (Complement‑ARIE) program, focused on developing, validating, and standardizing new approach methodologies (NAMs) — including advanced in vitro and computational models that better reflect human biology. Key elements of the initiative include: Establishment of Technology Development Centers to accelerate NAM development A NAMs data hub and coordinating center to support data sharing and standards A validation and qualification network to enable regulatory acceptance through public‑private collaboration Initial pilot projects in areas such as inhalation toxicity, developmental neurotoxicity,…
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New Video: Advancing Engine Emissions Research at SR Technicss
Following the successful installation of the VITROCELL AirTox Monitor at the SR Technics Group test facilities, we’re excited to see it already fully integrated into ongoing emissions research. Watch the video: https://lnkd.in/de49AXcG In collaboration with the Adolphe Merkle Institute and ZHAW School of Engineering, advanced in vitro exposure at the air–liquid interface is now being applied to deepen the understanding of jet engine emissions. We’re looking forward to further progress within the JETSTREAM project and to driving innovation in next-generation in vitro testing methods. More Information Firmenkontakt und Herausgeber der Meldung: VITROCELL Systems GmbH Fabrik Sonntag 3 79183 Waldkirch Telefon: +49 (7681) 4977950 http://www.vitrocell.com Ansprechpartner: Tobias Krebs Managing Director Telefon:…
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Why suspend a powder if you don’t have to?
Dry Powder Exposure Systems enable the direct aerosolization of dry powders — without first transferring them into suspension. This exposure principle is especially valuable when: only very small quantities of material are available test substances should be evaluated in their native particulate form maximum material efficiency is required By aerosolizing dry powders directly into the exposure chamber, researchers can generate dose-response profiles while preserving scarce and high-value materials, such as novel drug candidates. At which stage does dry powder exposure become critical in your research workflow? More information Firmenkontakt und Herausgeber der Meldung: VITROCELL Systems GmbH Fabrik Sonntag 3 79183 Waldkirch Telefon: +49 (7681) 4977950 http://www.vitrocell.com Ansprechpartner: Tobias Krebs Managing…
