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VITROCELL® holder systems for e-cigarettes
New designs of electronic cigarettes such as ENDS (Electronic Nicotine Delivery Systems) products or HTP (Heated Tobacco Products) lead to a large variety of different shapes which make the insertion into conventional holders with labyrinth seals impossible. VITROCELL® has developed a new holder system which is flexible to adjust to different shapes. Thus, all e-cigarettes can be used. The compatibility is tested with JUUL, myblu, Alto, Logic, IQOS, vype, GLO and tank products. VITROCELL®️ holders are tight, very solidly worked out, durable and easy to clean. They are compatible with all VITROCELL® Smoking Machines & Robots. In most cases the exchange of the inner sealing is sufficient to adjust for a…
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VITROCELL® TEM Grid holders for dose determination of airborne particles during in vitro Exposure at the air / liquid interface
. Background The assessment of toxicological effects of airborne particles to the human organism is of major importance in disease research. The presence of nano and ultrafine particles can be found both in indoor and outdoor atmospheres which include workplaces and living areas. Over the last years, the degree of contribution to diseases of such particles is analyzed ever more frequent by the use of in vitro methods. The required equipment for these studies consisting of aerosol generation and exposure systems are nowadays developed more and more to proven levels. Here the exposure of lung cells to particles at the air/liquid interface is the prime choice over submerse exposure conditions…
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Screening antiviraler pharmazeutischer Leitwirkstoffe gegen das Coronavirus (COVID-19 / SARS-CoV-2)
In der Inhalationstherapie werden pharmazeutische Präparate als Aerosole auf Zellen des Atemtraktes im Nasen- oder Lungenbereich appliziert. Zur präklinischen Entwicklung neuer Arzneimittel werden dafür oft kommerziell erhältliche, physiologisch relevante in vitro Zellkulturmodelle des Nasen-, Rachen- oder Lungenepithels verwendet. In jüngster Zeit wurden diese Modelle verfeinert, um SARS-CoV-2 Infektionen nachzuahmen. Bei der Entwicklung neuer Arzneimittel war es bisher üblich, die Zellkulturen ganz mit Zellkulturmedium zu bedecken und die zu testenden Wirkstoffe ins Zellkulturmedium zu geben. Dieses submerse Expositionsverfahren stellt allerdings eine unphysiologische Applikationsform dar, da die Substanzen mit dem Zellkulturmedium interagieren und die Zellen demnach eine andere Dosis und Formulierung erhalten können als ursprünglich geplant. Darüber hinaus produzieren Lungenepithelzellen in submersen…
